Animal-Free Recombinant Human TGF-β3 0 评论Submit a Review 产品详情 产品编号: AF-100-36E 产品描述: The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Transforming Growth Factor-β3 AA Sequence (monomer): ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 25 kDa Accession Number: P10600 Gene ID: 7043 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Mouse, Rat, Salamander References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 癌症 细胞培养 免疫系统 炎症 神经生物学 干细胞&分化 TGF-β超家族 创伤修复 过敏 product.subtitle.recentcitations 第一作者 Harberts, J 标题 Robust neuronal differentiation of human iPSC-derived neural progenitor cells cultured on densely-spaced spiky silicon nanowire arrays 文献引用 Scientific Reports; 11(1) pg18819 PubMed Id 34552130 第一作者 Li, L 标题 A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation 文献引用 Nature Metabolism; 3(9) pg1242-1258 PubMed Id 34504353 第一作者 Saini, C 标题 Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions 文献引用 Scientific Reports; 10(1) pg15143 PubMed Id 32934336