Recombinant Murine RELMβ 0 评论Submit a Review 产品详情 产品编号: 450-26B 产品描述: RELMβ (Resistin-like molecule β/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokines, resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond. Source: E.coli Synonyms: Resistin-like β, Cysteine-rich secreted protein FIZZ2 AA Sequence (monomer): MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 18 kDa Accession Number: Q99P86 Gene ID: 57263 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Parasite, Pig Intestinal Worm References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 糖尿病/体重调节 免疫系统 炎症 product.subtitle.recentcitations 第一作者 LeMessurier, K S 标题 Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta. 文献引用 Scientific Reports; 8(1) pg7061 PubMed Id 29728628 第一作者 Steinbrecher, K A 标题 Murine guanylate cyclase C regulates colonic injury and inflammation. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 186(12) pg7205-14 PubMed Id 21555532 第一作者 Herbert, D R 标题 Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. 文献引用 The Journal of Experimental Medicine; 206(13) pg2947-57 PubMed Id 19995957