Growth Factors & Cytokines

Recombinant Murine RELMβ

Product Details

Catalogue Number: 450-26B
Description:

RELMβ (Resistin-like molecule β/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokines, resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond.

Source: E.coli

Synonyms: Resistin-like β, Cysteine-rich secreted protein FIZZ2

AA Sequence (monomer): MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 18 kDa

Accession Number: Q99P86

Gene ID: 57263

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
LeMessurier, K S
Title
Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta.
Citation
Scientific Reports; 8(1) pg7061
PubMed Id
First Author
Steinbrecher, K A
Title
Murine guanylate cyclase C regulates colonic injury and inflammation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 186(12) pg7205-14
PubMed Id
First Author
Herbert, D R
Title
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.
Citation
The Journal of Experimental Medicine; 206(13) pg2947-57
PubMed Id