Recombinant Human sRANK Receptor 0 AvisSubmit a Review Détails du Produit Catalog Number: 310-08 Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic. These dendritic cells then stimulate naïve T-cell proliferation, and promote the survival of RANK + T-cells. RANK is also expressed in a variety of tissues, including skeletal muscle, thymus, liver, colon, small intestine, and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis, and in dendritic cell-mediated T-cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget's disease of bone (PDB2). Recombinant Human sRANK Receptor is a 19.3 kDa polypeptide containing the TNFR-homologous, cysteine-rich portion of the extracellular domain of RANK receptor (175 amino acid residues). Source: E.coli Synonyms: TNFRSF11A, ODFR (osteoclast differentiation factor receptor), ODAR (osteoclast differentiation and activation receptor), TRANCE Receptor AA Sequence: MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit sRANKL induced NF-κB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect in the presence of 15 ng/ml of recombinant sRANKL, is 30-50 ng/ml. Calculated Molecular Weight: 19.3 kDa Accession Number: Q9Y6Q6 Gene ID: 8792 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Diabetes/Weight Regulation Immune System Receptors TNF Superfamily product.subtitle.recentcitations Premier Auteur Newa, M Titre Antibody-mediated "universal" osteoclast targeting platform using calcitonin as a model drug. Citation Pharmaceutical Research; 28(5) pg1131-43 Id PubMed 21301934 Premier Auteur Irie, A Titre Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity. Citation Bone; 41(2) pg165-74 Id PubMed 17560185