Recombinant Human/Murine/Rat Myostatin 0 AvisSubmit a Review Détails du Produit Catalog Number: 120-00 Description: Myostatin is a TGF-β family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the activin-binding protein follistatin, and by the propeptide of myostatin. Recombinant Human/Murine/Rat Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. Source: E.coli Synonyms: GDF-8 AA Sequence (monomer): DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml. Calculated Molecular Weight: 25 kDa Accession Number: O14793 Gene ID: 2660 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Stem Cells & Differentiation product.subtitle.recentcitations Premier Auteur Verzola, D Titre Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy. Citation Scientific Reports; 10(1) pg6343 Id PubMed 32286342 Premier Auteur Walker, R G Titre Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice Citation Scientific Reports; 10(1) pg4561 Id PubMed 32165710 Premier Auteur Ozek, C Titre Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. Citation Scientific Reports; 8(1) pg17293 Id PubMed 30470794