Recombinant Human BRAK (CXCL14) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-50 Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α and β. Recombinant Human BRAK is a 9.4 kDa protein containing 77 amino acid residues. Source: E.coli Synonyms: Breast and Kidney-expressed chemokine, CXCL14, bolekine, NJAC AA Sequence: SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml. Calculated Molecular Weight: 9.4 kDa Accession Number: O95715 Gene ID: 9547 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Chemotaxis Immune System Wound Healing product.subtitle.recentcitations First Author Lee, A W Title A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Citation The Journal of Biological Chemistry; 294(29) pg11199-11212 PubMed Id 31167786 First Author Alenazi, Y Title Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Citation Scientific Reports; 8(1) pg6333 PubMed Id 29679010 First Author Costa, A Title Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer. Citation Cancer Cell; 33(3) pg463-479.e10 PubMed Id 29455927
