Recombinant Human IL-17D 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-27 Description: IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony-forming assays. Recombinant Human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains. Source: E.coli Synonyms: Interleukin-17D AA Sequence (monomer): APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT LQLGPREQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR ISYDPARYPR YLPEAYCLCR GCLTGLFGEE DVRFRSAPVY MPTVVLRRTP ACAGGRSVYT EAYVTIPVGC TCVPEPEKDA DSINSSIDKQ GAKLLLGPND APAGP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 40.5 kDa Accession Number: Q8TAD2 Gene ID: 53342 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Bone, Skeletal, Cartilage Immune System product.subtitle.recentcitations First Author Silacci, M Title Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency. Citation The Journal of Biological Chemistry; 289(20) pg14392-8 PubMed Id 24692552 First Author Perona-Wright, G Title Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Citation Proceedings of the National Academy of Sciences of the United States of America; 109(45) pg18535-40 PubMed Id 23091017 First Author Nguyen, H V Title The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells. Citation Blood; 119(18) pg4174-81 PubMed Id 22438254
