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Recombinant Human IL-17D

Product Details

Catalogue Number: 200-27
Description:

IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains.  It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony-forming assays.  Recombinant Human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

Source: E.coli

Synonyms: Interleukin-17D

AA Sequence (monomer): APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT LQLGPREQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR ISYDPARYPR YLPEAYCLCR GCLTGLFGEE DVRFRSAPVY MPTVVLRRTP ACAGGRSVYT EAYVTIPVGC TCVPEPEKDA DSINSSIDKQ GAKLLLGPND APAGP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 40.5 kDa

Accession Number: Q8TAD2

Gene ID: 53342

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Silacci, M
Title
Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency.
Citation
The Journal of Biological Chemistry; 289(20) pg14392-8
PubMed Id
First Author
Perona-Wright, G
Title
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 109(45) pg18535-40
PubMed Id
First Author
Nguyen, H V
Title
The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells.
Citation
Blood; 119(18) pg4174-81
PubMed Id