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Recombinant Human IL-17E

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Product Details

Catalogue Number: 200-24
Description:
Recombinant Human IL-17E

IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulates secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant Human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 146 amino acid polypeptide chains.

Source: E.coli

Synonyms: Interleukin-17E, IL-25

AA Sequence (monomer): MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100 ng/ml.

Calculated Molecular Weight: 33.8 kDa

Accession Number: Q9H293

Gene ID: 64806

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Han, K
Title
A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.
Citation
Journal of immunology (Baltimore, Md. : 1950); 201(5) pg1382-1388
PubMed Id
First Author
Silacci, M
Title
Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency.
Citation
The Journal of Biological Chemistry; 289(20) pg14392-8
PubMed Id