Recombinant Human IL-13 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-13 Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues. Source: E.coli Synonyms: NC30 (Human), P600 (Murine) AA Sequence: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.6 kDa Accession Number: P35225 Gene ID: 3596 crossreactivity: Bacteria, Human, Human + Mouse, Monkey, Mouse, Pig References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Stem Cells & Differentiation Allergy product.subtitle.recentcitations First Author Miller, J L Title The mannose receptor mediates dengue virus infection of macrophages. Citation PLoS Pathogens; 4(2) pge17 PubMed Id 18266465 First Author Steins, A Title High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1. Citation EMBO reports; 21(5) pge48780 PubMed Id 32173982 First Author Dimou, P Title The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis. Citation Scientific Reports; 9(1) pg8348 PubMed Id 31171837 product.subtitle.productreviews Existing reviews Good I have used the vial before in the lab, and have got the desired results. that is why I have ordwred the same vial again. because I trust the product From: E | Date: 27.08.2020 × Good I have used the vial before in the lab, and have got the desired results. that is why I have ordwred the same vial again. because I trust the product From: E | Date: 27.08.2020 Close
