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Wachstumsfaktoren & Zytokine

Recombinant Human IL-4

Produktdetails

Katalognummer: 200-04
Beschreibung:

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

Source: E.coli

Synonyms: BCGF, BCDF, B cell stimulating factor (BSF-1)

AA Sequence: MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Calculated Molecular Weight: 15.1 kDa

Accession Number: P05112

Gene ID: 3565

crossreactivity: Research Interest

Country Of Origin: USA

Not for human use.

product.subtitle.productreviews

Vorliegende Bewertungen
hIL4
Good product. Used for in vitro culture to derive BMDCs.
Von:  Kevin | Datum:  26.08.2020
Great for APCs
Used to differentiate APCs, works very consistently
Von:  Laura | Datum:  26.08.2020
MDSCs
Used to differentiate PBMCs into MDSCs. Works well.
Von:  Max | Datum:  27.08.2020