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Recombinant Murine Flt3-Ligand

Product Details

Catalogue Number: 250-31L
Description:
Recombinant Murine Flt3-Ligand

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand has no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Murine Flt3-Ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues.

Source: E.coli

Synonyms: Fms-related tyrosine kinase 3 ligand, FltL

AA Sequence: MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 5.0 – 8.0 ng/ml.

Calculated Molecular Weight: 18.6 kDa

Accession Number: P49772

Gene ID: 14256

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Anderson, D A
Title
Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8.
Citation
The Journal of Experimental Medicine; 219(2)
PubMed Id
First Author
Xiong, W
Title
Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis.
Citation
Advanced science (Weinheim, Baden-Wurttemberg, Germany); pge2103029
PubMed Id
First Author
Singh Rawat, B
Title
Methionine- and Choline-Deficient Diet Identifies an Essential Role for DNA Methylation in Plasmacytoid Dendritic Cell Biology.
Citation
Journal of immunology (Baltimore, Md. : 1950); 208(4) pg881-897
PubMed Id

product.subtitle.productreviews

Existing reviews
Recombinant Murin Flt3-Ligand
We use this product in our murine media. Upon arrival we make stock dilutions. They keep well in -20 until we are ready to prep more media
From:  Nichole | Date:  26.08.2020