MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1
GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to chemoattract murine BW5147.3 cells using a concentration range of 1-30 ng/ml.
Calculated Molecular Weight:
Not for human use.