Recombinant Murine MDC (CCL22)

Product Details

Catalogue Number: 250-23

Description:

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1

AA Sequence: GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract murine BW5147.3 cells using a concentration range of 1-30 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: O88430

Gene ID: 20299

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Mouse

Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author

Lee, K M

Title

CCL17 in Inflammation and Pain.

Citation

Journal of immunology (Baltimore, Md. : 1950); 205(1) pg213-222

PubMed Id

32461237

First Author

Sakai, R

Title

Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4⁺ Treg axis during remission of crescentic glomerulonephritis.

Citation

Clinical & translational immunology; 9(11) pge1203

PubMed Id

33163184

First Author

Yagawa, Y

Title

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Citation

Scientific Reports; 7(1) pg15996

PubMed Id

29167448

Chemokine