Recombinant Human MDC (CCL22) (69 a.a.) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-36A Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1 Source: E.coli AA Sequence: GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTSDSCPRPG VVLLTFRDKE ICADPRVPWV KMILNKLSQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 8.1 kDa Accession Number: O00626 Gene ID: 6367 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Hamster, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Wound Healing product.subtitle.recentcitations First Author Lee, A W Title A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Citation The Journal of Biological Chemistry; 294(29) pg11199-11212 PubMed Id 31167786 First Author Alenazi, Y Title Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Citation Scientific Reports; 8(1) pg6333 PubMed Id 29679010 First Author Singh, K Title Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Citation Scientific Reports; 7(1) pg4267 PubMed Id 28655871
