Wachstumsfaktoren & Zytokine

Recombinant Rat IL-1α

Product Details

Catalogue Number: 400-01A
Description:

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells.  Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.  These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and  the release of prostaglandin and collagenase from synovial cells.  However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.  Recombinant Rat IL-1α is a 17.7 kDa protein containing 155 amino acid residues.

Source: E.coli

Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence: MAPHSFQNNL RYKLIRIVKQ EFIMNDSLNQ NIYVDMDRIH LKAASLNDLQ LEVKFDMYAY SSGGDSKYPV TLKVSNTQLF VSAQGEDKPV LLKEIPETPK LITGSETDLI FFWEKINSKN YFTSAAFPEL LIATKEQSQV HLARGLPSMI DFQIS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of murine D10S cells is ≤ 0.005 ng/ml, corresponding to a specific activity of ≥ 2 x 108 units/mg.

Calculated Molecular Weight: 17.7 kDa

Accession Number: P16598

Gene ID: 24493

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Chen, X
Title
PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL-1β-treated rat chondrocytes.
Citation
FEBS Open Bio; 11(2) pg435-445
PubMed Id
First Author
Bhargava, P
Title
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation.
Citation
The Journal of Clinical Investigation; 130(7) pg3467-3482
PubMed Id
First Author
Chang, H
Title
Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats.
Citation
Journal of immunology (Baltimore, Md. : 1950); 177(6) pg3635-43
PubMed Id