Recombinant Rat IL-1α 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-01A Description: IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Rat IL-1α is a 17.7 kDa protein containing 155 amino acid residues. Source: E.coli Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) AA Sequence: MAPHSFQNNL RYKLIRIVKQ EFIMNDSLNQ NIYVDMDRIH LKAASLNDLQ LEVKFDMYAY SSGGDSKYPV TLKVSNTQLF VSAQGEDKPV LLKEIPETPK LITGSETDLI FFWEKINSKN YFTSAAFPEL LIATKEQSQV HLARGLPSMI DFQIS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of murine D10S cells is ≤ 0.005 ng/ml, corresponding to a specific activity of ≥ 2 x 108 units/mg. Calculated Molecular Weight: 17.7 kDa Accession Number: P16598 Gene ID: 24493 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Scott, K M Title miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro. Citation Journal of Cellular Biochemistry; 123(6) pg1053-1063 PubMed Id 35362116 First Author Chen, X Title PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL-1β-treated rat chondrocytes. Citation FEBS Open Bio; 11(2) pg435-445 PubMed Id 33326693 First Author Bhargava, P Title Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation. Citation The Journal of Clinical Investigation; 130(7) pg3467-3482 PubMed Id 32182223
