Chémokines

Recombinant Human NAP-2 (CXCL7)

Product Details

Catalogue Number: 300-14
Description:

NAP-2 is a CXC chemokine that can signal through the CXCR1 and CXCR2 receptors.  It is produced in leukocytes by enzymatic processing of a precursor called platelet basic protein (PBP).  NAP-2 chemoattracts and activates neutrophils.  Recombinant Human NAP-2 protein is a 7.6 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines, and also the “ELR” motif, common to CXC chemokines that bind to CXCR1 and CXCR2.

Source: E.coli

Synonyms: Neutrophil Activating Protein-2, CXCL7, PBP (parent molecule), CTAP-III (precursor)

AA Sequence: AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 7.6 kDa

Accession Number: P02775

Gene ID: 5473

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Power, C A
Title
Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
Citation
The Journal of Experimental Medicine; 186(6) pg825-35
PubMed Id
First Author
Tiffany, H L
Title
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
Citation
The Journal of Experimental Medicine; 186(1) pg165-70
PubMed Id
First Author
Lee, A W
Title
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Citation
The Journal of Biological Chemistry; 294(29) pg11199-11212
PubMed Id