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Facteurs de Croissance et Cytokines

Recombinant Human Noggin

Product Details

Catalogue Number: 120-10C
Recombinant Human Noggin

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures.  Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14.  Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

Source: HEK293 cells

Synonyms: None


Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.

Recombinant Human Noggin Biological Activity Graph

Calculated Molecular Weight: 46 kDa

Accession Number: Q13253

Gene ID: 9241

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)


1mg will be provided as 2x500μg.

Country Of Origin: USA

Not for human use.

Research Interest


First Author
Niu, Y
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select.
Nature Genetics; 54(12) pg1983-1993
PubMed Id
First Author
Nguyen, V V
A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles.
Journal Of Extracellular Vesicles; 11(11) pge12280
PubMed Id
First Author
Zhao, Y
Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(22) pge2201539
PubMed Id


Existing reviews
It works well
It works well in organoid culture
From:  Eun Joo | Date:  08/07/2020
Necessary for organoid growth
Recombinant Human Noggin is one of the critical niche components for organoid growth media.
Delivered quickly.
From:  Kushtrim | Date:  09/07/2020
Human Noggin
Great product - works perfectly for organoid media. Shipped very quickly.
From:  Neel | Date:  21/07/2020
Excellent quality
We utilize H. Noggin for lung cancer organoid media and so far it has given us amazing results. The order was processed in a timely manner as well.
From:  Dora | Date:  24/07/2020
Good quality and good price
This product worked well for my project.  The price is reasonable and lower than most of vendors.
From:  Jin | Date:  26/08/2020
Recombinant Human Noggin for Organoid Media
Recombinant Human Noggin essential for organoid growth media. I used it for growing CRC organoids. Works very well and quick delivery. Recommend for any organoid media.
From:  Ilias | Date:  26/08/2020
good product
We routinely purchase Recombinant Human Noggin for our breast cancer organoid media. Peprotech has been easy to work with, quick to respond to questions, ship fast, and have had no issues with the product.
From:  Mark | Date:  26/08/2020
Rec Human Noggin
I have used this for the stem cell/organoid  culture for almost two years now. I am very happy with consistency of the product. In general, Peprotech has been a trust-able vendor for our lab needs.
From:  Arpit | Date:  26/08/2020
Perfect for organoids
We have purchased several products from peprotech to prepare our culture media for pancreatic organoids and the delivery was quick. This hNoggin works perfectly for us!
From:  Pilar | Date:  27/08/2020
Human Noggin for Lung Organoid Culture
Successfully cultured Lung Adenocarcinoma Organoid Culture. Mouse Noggin also works.
Very Quick Overnight Delivery.
Works great.
From:  Hardik | Date:  31/08/2020
Vital for Organoid Culture
PeproTech delivered the protein very quickly and Noggin is a vital part of our organoid culture.
From:  Connor | Date:  24/08/2021