Recombinant Murine Exodus-2 (CCL21) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-13 Description: Exodus-2 is a CC chemokine that can signal through the CCR7 receptor. It is expressed in lymphatic endothelial cells, the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant Murine Exodus-2 is a 12.0 kDa protein containing 110 amino acid residues. Source: E.coli Synonyms: CCL21, 6Ckine, SLC AA Sequence: SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human activated T cells cultured in the presence of IL-2 using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 12 kDa Accession Number: P86793 Gene ID: 65956 Note: 1mg will be provided as 2x500μg. crossreactivity: Bacteria, Human, Human + Mouse, Leech, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Wound Healing product.subtitle.recentcitations First Author Reijmers, R M Title Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. Citation Blood; 117(23) pg6162-71 PubMed Id 21471524 First Author López-Cotarelo, P Title A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. Citation The Journal of Biological Chemistry; 290(2) pg827-40 PubMed Id 25425646 First Author Stolp, B Title HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo. Citation Proceedings of the National Academy of Sciences of the United States of America; 109(45) pg18541-6 PubMed Id 23093676
