Chémokines

Recombinant Murine Exodus-2 (CCL21)

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Product Details

Catalogue Number: 250-13
Description:

Exodus-2 is a CC chemokine that can signal through the CCR7 receptor. It is expressed in lymphatic endothelial cells, the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant Murine Exodus-2 is a 12.0 kDa protein containing 110 amino acid residues.

Source: E.coli

Synonyms: CCL21, 6Ckine, SLC

AA Sequence: SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human activated T cells cultured in the presence of IL-2 using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 12 kDa

Accession Number: P86793

Gene ID: 65956

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Reijmers, R M
Title
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.
Citation
Blood; 117(23) pg6162-71
PubMed Id
First Author
López-Cotarelo, P
Title
A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
Citation
The Journal of Biological Chemistry; 290(2) pg827-40
PubMed Id
First Author
Stolp, B
Title
HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 109(45) pg18541-6
PubMed Id