Facteurs de Croissance et Cytokines

Recombinant Rat Leptin

Product Details

Catalogue Number: 400-21
Description:

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.

Source: E.coli

Synonyms: Obesity protein (OB)

AA Sequence: MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls.

Calculated Molecular Weight: 16.2 kDa

Accession Number: P50596

Gene ID: 25608

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Foright, R M
Title
Compensatory eating behaviors in male and female rats in response to exercise training.
Citation
American journal of physiology. Regulatory, integrative and comparative physiology; 319(2) pgR171-R183
PubMed Id
First Author
Grases-Pintó, B
Title
Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation.
Citation
Scientific Reports; 9(1) pg1786
PubMed Id
First Author
Jaubert, A
Title
Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release.
Citation
PLoS ONE; 7(7) pge40650
PubMed Id