Recombinant Rat Leptin 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-21 Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls. Calculated Molecular Weight: 16.2 kDa Accession Number: P50596 Gene ID: 25608 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author Foright, R M Title Compensatory eating behaviors in male and female rats in response to exercise training. Citation American journal of physiology. Regulatory, integrative and comparative physiology; 319(2) pgR171-R183 PubMed Id 32551825 First Author Grases-Pintó, B Title Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation. Citation Scientific Reports; 9(1) pg1786 PubMed Id 30742004 First Author Jaubert, A Title Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release. Citation PLoS ONE; 7(7) pge40650 PubMed Id 22808220
