Recombinant Human IL-1β

제품 상세

카다로그 번호 200-01B

제품 설명

IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Source: E.coli

Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence: APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 10⁹ units/mg.

Note:

1mg will be provided as 2x500μg.

Cross Reactivity:

Bacteria, Cow, Frog, Horse, Human , Human + Hamster, Human + Rat, Monkey, Mouse, Mouse + Chicken, Pig, Rabbit, Rat, Sheep

Research Interest

Immune System

Inflammation

Neurobiology

Stem Cells & Differentiation

Wound Healing

Angiogenesis/Cardiovascular

Allergy

Transplantation

Bone, Skeletal, Cartilage

Cancer

Diabetes/Weight Regulation

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

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Human lymphatic endothelial cells express multiple functional TLRs.

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Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3.

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Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells.

The Journal of Biological Chemistry; 283(44) pg29983-92

31 Oct 2008

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Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.

Journal of immunology (Baltimore, Md. : 1950); 181(7) pg5082-8

1 Oct 2008

18802112
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Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.

BMC Immunology; 9 pg56

1 Oct 2008

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Miyahara, Y

Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America; 105(40) pg15505-10

7 Oct 2008

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A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.

Journal of immunology (Baltimore, Md. : 1950); 181(8) pg5606-17

15 Oct 2008

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Interferon-alpha controls IL-17 expression in vitro and in vivo.

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0 2008

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Pecaric-Petkovic, T

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.

Blood; 113(7) pg1526-34

12 Feb 2009

18955562
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Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.

Journal of immunology (Baltimore, Md. : 1950); 181(11) pg8053-67

1 Dec 2008

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Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.

Journal of immunology (Baltimore, Md. : 1950); 181(12) pg8382-90

15 Dec 2008

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.

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29 Jan 2009

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10 Dec 2008

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Haniffa, M

Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation.

The Journal of Experimental Medicine; 206(2) pg371-85

16 Feb 2009

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Argaw, A T

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.

Proceedings of the National Academy of Sciences of the United States of America; 106(6) pg1977-82

10 Feb 2009

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Helmy, A

Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.

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0 Apr 2009

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Pretzel, D

In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.

Arthritis research & therapy; 11(1) pgR25

0 2009

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A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.

PLoS Pathogens; 5(2) pge1000308

0 Feb 2009

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MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.

Journal of immunology (Baltimore, Md. : 1950); 182(6) pg3650-9

15 Mar 2009

19265143
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Bazzoni, F

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals.

Proceedings of the National Academy of Sciences of the United States of America; 106(13) pg5282-7

31 Mar 2009

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Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.

PLoS ONE; 4(3) pge4902

0 2009

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Chong, H C

Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.

The Journal of Cell Biology; 184(6) pg817-31

23 Mar 2009

19307598
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IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.

Journal of immunology (Baltimore, Md. : 1950); 182(8) pg5003-12

15 Apr 2009

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Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

Immunity; 30(4) pg576-87

17 Apr 2009

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Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.

The Journal of Experimental Medicine; 206(6) pg1291-301

8 Jun 2009

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A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Journal of immunology (Baltimore, Md. : 1950); 183(1) pg732-9

1 Jul 2009

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Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.

Journal of immunology (Baltimore, Md. : 1950); 183(1) pg66-74

1 Jul 2009

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The Journal of Biological Chemistry; 284(38) pg25900-11

18 Sep 2009

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Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950); 183(3) pg1838-45

1 Aug 2009

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Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression.

The Journal of Biological Chemistry; 284(40) pg27402-8

2 Oct 2009

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Giannoni, P

Short-time survival and engraftment of bone marrow stromal cells in an ectopic model of bone regeneration.

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0 Feb 2010

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Tsukamoto, N

Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research; 15(18) pg5733-43

15 Sep 2009

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Vigetti, D

Modulation of hyaluronan synthase activity in cellular membrane fractions.

The Journal of Biological Chemistry; 284(44) pg30684-94

30 Oct 2009

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Developmental switch of the expression of ion channels in human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950); 183(7) pg4483-92

1 Oct 2009

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Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes.

The international journal of biochemistry & cell biology; 42(1) pg113-9

0 Jan 2010

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Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

Proceedings of the National Academy of Sciences of the United States of America; 106(38) pg16339-44

22 Sep 2009

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Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin.

PLoS Pathogens; 5(10) pge1000622

0 Oct 2009

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Regulation of pentraxin-3 by antioxidants.

British Journal of Anaesthesia; 103(6) pg833-9

0 Dec 2009

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PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.

The Journal of Biological Chemistry; 285(3) pg2077-89

15 Jan 2010

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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.

The Journal of Biological Chemistry; 285(5) pg3191-200

29 Jan 2010

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An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells.

Human reproduction (Oxford, England); 25(2) pg510-8

0 Feb 2010

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Kishuku, M

Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.

Journal of immunology (Baltimore, Md. : 1950); 183(12) pg8176-85

15 Dec 2009

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Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.

The Journal of Biological Chemistry; 285(8) pg5888-95

19 Feb 2010

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Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.

Molecular Cancer; 9 pg1

5 Jan 2010

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The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B.

Journal of immunology (Baltimore, Md. : 1950); 184(6) pg3157-63

15 Mar 2010

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Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.

PLoS ONE; 5(3) pge9730

18 Mar 2010

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Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.

Molecular Pain; 6 pg19

9 Apr 2010

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Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.

PLoS ONE; 5(4) pge10091

8 Apr 2010

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Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.

The Journal of Biological Chemistry; 285(27) pg20607-14

2 Jul 2010

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Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

The Journal of Biological Chemistry; 285(29) pg22426-36

16 Jul 2010

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RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.

Journal of immunology (Baltimore, Md. : 1950); 184(11) pg6161-9

1 Jun 2010

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Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.

Immunity; 32(5) pg654-69

28 May 2010

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Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.

Blood; 116(7) pg1124-31

19 Aug 2010

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Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.

Journal of immunology (Baltimore, Md. : 1950); 184(11) pg6492-503

1 Jun 2010

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High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.

PLoS ONE; 5(5) pge10843

26 May 2010

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Vigetti, D

Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway.

The Journal of Biological Chemistry; 285(32) pg24639-45

6 Aug 2010

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Ombetta, J

Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.

PLoS ONE; 5(6) pge10914

1 Jun 2010

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Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.

Proceedings of the National Academy of Sciences of the United States of America; 107(24) pg10961-6

15 Jun 2010

20534450
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IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.

Journal of immunology (Baltimore, Md. : 1950); 185(2) pg1063-70

15 Jul 2010

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Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.

Journal of immunology (Baltimore, Md. : 1950); 185(3) pg1544-9

1 Aug 2010

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IL-17 immunity in human type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950); 185(3) pg1959-67

1 Aug 2010

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Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.

BMC Immunology; 11 pg38

9 Jul 2010

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Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.

Immunity; 32(6) pg803-14

25 Jun 2010

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Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.

Journal of inflammation (London, England); 7 pg37

27 Jul 2010

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E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.

The Journal of Biological Chemistry; 285(39) pg30042-9

24 Sep 2010

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Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.

PLoS ONE; 5(7) pge11740

23 Jul 2010

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Low-strength T-cell activation promotes Th17 responses.

Blood; 116(23) pg4829-37

2 Dec 2010

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The detrimental effects of IFN-Î± on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.

Journal of immunology (Baltimore, Md. : 1950); 185(7) pg4457-69

1 Oct 2010

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STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood; 117(1) pg165-74

6 Jan 2011

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Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1.

Journal of immunology (Baltimore, Md. : 1950); 185(10) pg6244-52

15 Nov 2010

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Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.

Journal of immunology (Baltimore, Md. : 1950); 185(11) pg6636-45

1 Dec 2010

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Cleavage of the NF-ÎºB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae.

The Journal of Biological Chemistry; 285(53) pg41320-7

31 Dec 2010

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Function of partially duplicated human Î±77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.

The Journal of Biological Chemistry; 286(1) pg594-606

7 Jan 2011

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Deactivation of STAT6 through serine 707 phosphorylation by JNK.

The Journal of Biological Chemistry; 286(5) pg4003-10

4 Feb 2011

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Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Blood; 117(9) pg2625-39

3 Mar 2011

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Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.

Journal of immunology (Baltimore, Md. : 1950); 186(3) pg1828-39

1 Feb 2011

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FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.

The Journal of Biological Chemistry; 286(10) pg8338-48

11 Mar 2011

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IL-1Î² is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.

Journal of immunology (Baltimore, Md. : 1950); 186(3) pg1870-9

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A novel TLR3 inhibitor encoded by African swine fever virus (ASFV).

Archives of Virology; 156(4) pg597-609

0 Apr 2011

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IÎºB kinase Î² regulates epithelium migration during corneal wound healing.

PLoS ONE; 6(1) pge16132

17 Jan 2011

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LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).

PLoS ONE; 6(1) pge16427

24 Jan 2011

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Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4Î±.

BMC Genomics; 12 pg128

25 Feb 2011

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The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.

PLoS ONE; 6(2) pge17160

22 Feb 2011

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Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.

Nature Protocols; 6(3) pg296-313

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Differentiation of inflammatory dendritic cells is mediated by NF-ÎºB1-dependent GM-CSF production in CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950); 186(9) pg5468-77

1 May 2011

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Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential.

Stem Cells International; 2011 pg235176

3 Mar 2011

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Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.

The Journal of Biological Chemistry; 286(21) pg18969-81

27 May 2011

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Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.

The Journal of Biological Chemistry; 286(23) pg20727-35

10 Jun 2011

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The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes.

The Journal of Biological Chemistry; 286(21) pg18681-91

27 May 2011

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Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.

Cell death & disease; 2 pge152

28 Apr 2011

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Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

PLoS ONE; 6(4) pge19103

29 Apr 2011

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Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFÎ±, NFÎºB, p38 and caspase 8 dependent pathways.

Journal of Neuroinflammation; 8 pg46

11 May 2011

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The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.

Annals of the Rheumatic Diseases; 70(9) pg1556-61

0 Sep 2011

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Eitz Ferrer, P

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-Î²-dependent induction of pro-apoptotic Noxa.

PLoS Pathogens; 7(6) pge1002083

0 Jun 2011

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Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells.

Journal of immunology (Baltimore, Md. : 1950); 187(4) pg1778-87

15 Aug 2011

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A novel pro-lymphangiogenic function for Th17/IL-17.

Blood; 118(17) pg4630-4

27 Oct 2011

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Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.

PLoS ONE; 6(9) pge24202

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The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.

Journal of immunology (Baltimore, Md. : 1950); 187(8) pg3972-8

15 Oct 2011

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Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro.

PLoS ONE; 6(9) pge24831

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Wang, J

TNF-Î± and IL-1Î² promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.

The Journal of Biological Chemistry; 286(46) pg39738-49

18 Nov 2011

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ST2 and IL-33 in pregnancy and pre-eclampsia.

PLoS ONE; 6(9) pge24463

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Mycobacteria activate Î³Î´ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.

Cancer immunology, immunotherapy : CII; 61(4) pg535-47

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Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.

BMC Complementary and Alternative Medicine; 11 pg105

3 Nov 2011

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High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of Experimental Medicine; 209(1) pg157-71

16 Jan 2012

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Inhibition of apoptosis and NF-ÎºB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.

PLoS Pathogens; 7(12) pge1002430

0 Dec 2011

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Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway.

Journal of Neuroinflammation; 8 pg187

30 Dec 2011

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Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HÎ²D2 gene expression and IL-8 release.

PLoS ONE; 6(12) pge29148

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Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

Journal of immunology (Baltimore, Md. : 1950); 188(5) pg2419-26

1 Mar 2012

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Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes.

Journal of immunology (Baltimore, Md. : 1950); 188(5) pg2075-83

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Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function.

Blood; 119(13) pg3113-22

29 Mar 2012

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Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naÃ¯ve T cells into cytokine-producing mature T cells.

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Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

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Isoform-selective induction of human p110Î´ PI3K expression by TNFÎ±: identification of a new and inducible PIK3CD promoter.

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Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Blood; 119(17) pg3997-4008

26 Apr 2012

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Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCÎ´ pathway in human articular chondrocytes.

Journal of Cellular Biochemistry; 113(9) pg2856-65

0 Sep 2012

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Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).

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Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with BehÃ§et's disease.

Arthritis research & therapy; 14(3) pgR99

1 May 2012

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Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-ÎºB pathway independent of TRAF6, TAK1 and LUBAC.

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The Notch pathway attenuates interleukin 1Î² (IL1Î²)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.

The Journal of Biological Chemistry; 287(30) pg24978-89

20 Jul 2012

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K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.

Proceedings of the National Academy of Sciences of the United States of America; 109(25) pgE1629-37

19 Jun 2012

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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

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Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

The Journal of Biological Chemistry; 287(30) pg25139-50

20 Jul 2012

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DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.

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Liu, K

Characterization of the autocrine/paracrine function of vitamin D in human gingival fibroblasts and periodontal ligament cells.

PLoS ONE; 7(6) pge39878

0 2012

22761920
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Young, A

Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.

Journal of immunology (Baltimore, Md. : 1950); 189(5) pg2079-83

1 Sep 2012

22837488
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Rabenhorst, A

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood; 120(10) pg2042-54

6 Sep 2012

22837530
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Shih, K

Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1Î²-stimulated fibroblast-like synoviocytes.

PLoS ONE; 7(7) pge42389

0 2012

22860122
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Klawitter, M

Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.

Journal of inflammation (London, England); 9(1) pg29

21 Aug 2012

22909087
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Wang, J

The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers.

BMC Cancer; 12 pg418

21 Sep 2012

22994684
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Liu, M

Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion.

BMC Biotechnology; 12 pg68

25 Sep 2012

23006786
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Iyer, A

MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.

PLoS ONE; 7(9) pge44789

0 2012

23028621
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Landsberg, J

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.

Nature; 490(7420) pg412-6

18 Oct 2012

23051752
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Rossato, M

IL-10-induced microRNA-187 negatively regulates TNF-Î±, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.

Proceedings of the National Academy of Sciences of the United States of America; 109(45) pgE3101-10

6 Nov 2012

23071313
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Jeffery, L E

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.

Journal of immunology (Baltimore, Md. : 1950); 189(11) pg5155-64

1 Dec 2012

23087405
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Zhou, J

Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.

PLoS ONE; 7(11) pge49744

0 2012

23166763
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Humphrey, R K

Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic Î² cell death.

The Journal of Biological Chemistry; 288(4) pg2428-40

25 Jan 2013

23172226
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Holoshitz, J

An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.

Journal of immunology (Baltimore, Md. : 1950); 190(1) pg48-57

1 Jan 2013

23180817
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Fu, B

Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.

Proceedings of the National Academy of Sciences of the United States of America; 110(3) pgE231-40

15 Jan 2013

23271808
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Nair, S

Immunologic targeting of FOXP3 in inflammatory breast cancer cells.

PLoS ONE; 8(1) pge53150

0 2013

23341929
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Rousselle, A

CXCL5 limits macrophage foam cell formation in atherosclerosis.

The Journal of Clinical Investigation; 123(3) pg1343-7

0 Mar 2013

23376791
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Chen, Y

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.

PLoS Pathogens; 9(1) pge1003100

0 Jan 2013

23382671
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Luger, R

Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.

PLoS ONE; 8(2) pge54879

0 2013

23408948
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Ingvarsen, S

Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.

The Journal of Biological Chemistry; 288(15) pg10195-204

12 Apr 2013

23413031
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Mansur, D S

Poxvirus targeting of E3 ligase Î²-TrCP by molecular mimicry: a mechanism to inhibit NF-ÎºB activation and promote immune evasion and virulence.

PLoS Pathogens; 9(2) pge1003183

0 Feb 2013

23468625
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Aziz, A

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.

The Journal of Clinical Investigation; 123(5) pg2169-82

0 May 2013

23543057
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Long, H M

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.

The Journal of Experimental Medicine; 210(5) pg933-49

6 May 2013

23569328
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Wang, H

Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.

The Journal of Biological Chemistry; 288(23) pg16761-74

7 Jun 2013

23589286
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Matta, J

Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.

Blood; 122(3) pg394-404

18 Jul 2013

23687088
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Liu, Y

TGF-Î² enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.

PLoS ONE; 8(5) pge64612

0 2013

23741351
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Spehlmann, M E

Trp53 deficiency protects against acute intestinal inflammation.

Journal of immunology (Baltimore, Md. : 1950); 191(2) pg837-47

15 Jul 2013

23772033
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Liu, X

USP18 inhibits NF-ÎºB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

The Journal of Experimental Medicine; 210(8) pg1575-90

29 Jul 2013

23825189
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Ferreira, E

Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.

The Journal of Biological Chemistry; 288(41) pg29494-505

11 Oct 2013

23970554
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Yan, D

Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage.

The Journal of Biological Chemistry; 288(44) pg31655-69

1 Nov 2013

24036113
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Dreymueller, D

Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.

Journal of immunology (Baltimore, Md. : 1950); 192(2) pg722-31

15 Jan 2014

24342803
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Nagasaki, T

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.

British Journal of Cancer; 110(2) pg469-78

21 Jan 2014

24346288
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Abe, T

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1Î² (IL-1Î²)-induced stabilization.

The Journal of Biological Chemistry; 289(7) pg3888-900

14 Feb 2014

24379400
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Sun, W

Interleukin-1Î² promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.

Cell death & disease; 5 pge1020

23 Jan 2014

24457964
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Tran, C M

CCN2 suppresses catabolic effects of interleukin-1Î² through Î±5Î²1 and Î±VÎ²3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.

The Journal of Biological Chemistry; 289(11) pg7374-87

14 Mar 2014

24464580
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Gu, M

Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.

Journal of immunology (Baltimore, Md. : 1950); 192(6) pg2846-56

15 Mar 2014

24534530
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De Kock, J

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response.

Stem cells (Dayton, Ohio); 32(8) pg2215-28

0 Aug 2014

24585677
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Oleson, B J

Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent Î³H2AX protein formation in pancreatic Î² cells.

The Journal of Biological Chemistry; 289(16) pg11454-64

18 Apr 2014

24610783
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Zhang, Y

KrÃ¼ppel-like factor 6 is a co-activator of NF-ÎºB that mediates p65-dependent transcription of selected downstream genes.

The Journal of Biological Chemistry; 289(18) pg12876-85

2 May 2014

24634218
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Nair, S K

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific Reports; 4 pg4632

23 Apr 2014

24755960
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Herr, F

IL-2 phosphorylates STAT5 to drive IFN-Î³ production and activation of human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950); 192(12) pg5660-70

15 Jun 2014

24829413
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Ben-Addi, A

IÎºB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.

Proceedings of the National Academy of Sciences of the United States of America; 111(23) pgE2394-403

10 Jun 2014

24912162
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Purvis, H A

A negative feedback loop mediated by STAT3 limits human Th17 responses.

Journal of immunology (Baltimore, Md. : 1950); 193(3) pg1142-50

1 Aug 2014

24973454
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Ouyang, C

Transforming growth factor (TGF)-Î²-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit Î± (PKACÎ±) and X-linked protein kinase (PRKX).

The Journal of Biological Chemistry; 289(35) pg24226-37

29 Aug 2014

25028512
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Donlin, L T

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

Journal of immunology (Baltimore, Md. : 1950); 193(5) pg2373-83

1 Sep 2014

25057003
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Epaulard, O

Macrophage- and neutrophil-derived TNF-Î± instructs skin langerhans cells to prime antiviral immune responses.

Journal of immunology (Baltimore, Md. : 1950); 193(5) pg2416-26

1 Sep 2014

25057007
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Yu, J

Noncanonical NF-ÎºB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.

Journal of immunology (Baltimore, Md. : 1950); 193(5) pg2574-86

1 Sep 2014

25063873
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De, S

EGF receptor uses SOS1 to drive constitutive activation of NFÎºB in cancer cells.

Proceedings of the National Academy of Sciences of the United States of America; 111(32) pg11721-6

12 Aug 2014

25071181
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Burton, B R

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.

Nature Communications; 5 pg4741

3 Sep 2014

25182274
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Humphrey, R K

Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.

The Journal of Biological Chemistry; 289(43) pg29994-30004

24 Oct 2014

25204656
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Mota, C

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950); 193(12) pg5854-62

15 Dec 2014

25367118
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Park, H

MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins.

The Journal of Biological Chemistry; 290(5) pg2831-41

30 Jan 2015

25505246
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Bushkin, Y

Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry.

Journal of immunology (Baltimore, Md. : 1950); 194(2) pg836-41

15 Jan 2015

25505292
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Tsukuda, S

Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.

The Journal of Biological Chemistry; 290(9) pg5673-84

27 Feb 2015

25550158
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Lourenco, S

Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.

Journal of immunology (Baltimore, Md. : 1950); 194(7) pg3463-74

1 Apr 2015

25712213
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Larena, M

Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling.

Journal of immunology (Baltimore, Md. : 1950); 194(8) pg3829-39

15 Apr 2015

25786687
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Benesch, M G

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.

Journal of Lipid Research; 56(6) pg1134-44

0 Jun 2015

25896349
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Cobo, E R

Colonic MUC2 mucin regulates the expression and antimicrobial activity of Î²-defensin 2.

Mucosal Immunology; 8(6) pg1360-72

0 Nov 2015

25921338
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Wilson, R P

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.

The Journal of Experimental Medicine; 212(6) pg855-64

1 Jun 2015

25941256
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Chadet, S

Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950); 195(2) pg651-60

15 Jul 2015

26078273
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Rustenhoven, J

An anti-inflammatory role for C/EBPÎ´ in human brain pericytes.

Scientific Reports; 5 pg12132

13 Jul 2015

26166618
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Zhu, H

Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis.

Scientific Reports; 5 pg12227

17 Jul 2015

26183847
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De, S

Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.

Proceedings of the National Academy of Sciences of the United States of America; 112(31) pg9680-5

4 Aug 2015

26195767
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Posch, B

Allergenic Can f 1 and its human homologue Lcn-1 direct dendritic cells to induce divergent immune responses.

Journal of Cellular and Molecular Medicine; 19(10) pg2375-84

0 Oct 2015

26218644
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Hammitzsch, A

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Proceedings of the National Academy of Sciences of the United States of America; 112(34) pg10768-73

25 Aug 2015

26261308
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Takami, M

Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.

Journal of immunology (Baltimore, Md. : 1950); 195(6) pg2520-3

15 Sep 2015

26276877
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Tong, W

In Vivo Identification and Induction of Articular Cartilage Stem Cells by Inhibiting NF-ÎºB Signaling in Osteoarthritis.

Stem cells (Dayton, Ohio); 33(10) pg3125-37

0 Oct 2015

26285913
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De Buck, M

Serum amyloid A1Î± induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.

Journal of Leukocyte Biology; 98(6) pg1049-60

0 Dec 2015

26297794
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Zhang, Z

Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.

The Journal of Clinical Investigation; 125(9) pg3692-703

0 Sep 2015

26301812
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Liu, J

Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-Îºb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.

Scientific Reports; 5 pg13558

1 Sep 2015

26324318
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Burzynski, L C

Interleukin-1Î± Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.

The Journal of Biological Chemistry; 290(41) pg25188-96

9 Oct 2015

26324711
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Lai, C

Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.

Journal of immunology (Baltimore, Md. : 1950); 195(8) pg3912-21

15 Oct 2015

26371257
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Schwartz, M P

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.

Proceedings of the National Academy of Sciences of the United States of America; 112(40) pg12516-21

6 Oct 2015

26392547
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Mailer, R K

IL-1Î² promotes Th17 differentiation by inducing alternative splicing of FOXP3.

Scientific Reports; 5 pg14674

6 Oct 2015

26441347
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Wee, Z N

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.

Nature Communications; 6 pg8746

27 Oct 2015

26503059
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Courth, L F

Crohn's disease-derived monocytes fail to induce Paneth cell defensins.

Proceedings of the National Academy of Sciences of the United States of America; 112(45) pg14000-5

10 Nov 2015

26512113
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Chen, P

Endothelial-to-mesenchymal transition drives atherosclerosis progression.

The Journal of Clinical Investigation; 125(12) pg4514-28

26 Oct 2015

26517696
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Riesenberg, S

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.

Nature Communications; 6 pg8755

4 Nov 2015

26530832
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Krock, E

Nerve Growth Factor Is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs.

The Journal of Biological Chemistry; 291(7) pg3541-51

12 Feb 2016

26668319
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Rustenhoven, J

Isolation of highly enriched primary human microglia for functional studies.

Scientific Reports; 6 pg19371

18 Jan 2016

26778406
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Hu, B

Heme oxygenase-1 attenuates IL-1Î² induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.

Scientific Reports; 6 pg21190

15 Feb 2016

26877238
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Liu, L

Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.

Scientific Reports; 6 pg21810

25 Feb 2016

26911452
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Yang, C

Differential expression of p38 MAPK Î±, Î², Î³, Î´ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration.

Scientific Reports; 6 pg22182

25 Feb 2016

26911458
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Chandrika, G

Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFÎºB and PKC-Î± signaling.

Scientific Reports; 6 pg22455

4 Mar 2016

26940200
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Drujont, L

RORÎ³t+ cells selectively express redundant cation channels linked to the Golgi apparatus.

Scientific Reports; 6 pg23682

24 Mar 2016

27009467
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Xu, W

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis.

Scientific Reports; 6 pg24042

4 Apr 2016

27041213
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Lombardo, G

Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.

Scientific Reports; 6 pg25689

9 May 2016

27157262
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Dardik, R

The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.

Molecular Vision; 22 pg548-62

0 2016

27293373
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Ha, Y

SOCS1 suppresses IL-1Î²-induced C/EBPÎ² expression via transcriptional regulation in human chondrocytes.

Experimental & molecular medicine; 48 pge241

24 Jun 2016

27339399
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Villalvilla, A

The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.

Scientific Reports; 6 pg29243

7 Jul 2016

27385438
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Mei, Z

Kelch-like Protein 21 (KLHL21) Targets IÎºB Kinase-Î² to Regulate Nuclear Factor Îº-Light Chain Enhancer of Activated B Cells (NF-ÎºB) Signaling Negatively.

The Journal of Biological Chemistry; 291(35) pg18176-89

26 Aug 2016

27387502
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Ma, C S

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

The Journal of Experimental Medicine; 213(8) pg1589-608

25 Jul 2016

27401342
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Mao, C

Double-edged-sword effect of IL-1Î² on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-ÎºB, MAPK and BMP/Smad signaling pathways.

Cell death & disease; 7 pge2296

14 Jul 2016

27415426
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Comte, D

Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America; 113(33) pg9321-6

16 Aug 2016

27482100
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Chiou, S

A novel role for Î²2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells.

Scientific Reports; 6 pg31035

9 Aug 2016

27503241
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Hong, C Y

Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells.

Experimental & molecular medicine; 48(8) pge253

19 Aug 2016

27538371
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Aggelakopoulou, M

ERÎ²-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950); 197(7) pg2598-609

1 Oct 2016

27549171
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Zhou, Q

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.

Proceedings of the National Academy of Sciences of the United States of America; 113(36) pg10127-32

6 Sep 2016

27559085
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Doherty, C M

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

The Journal of Biological Chemistry; 291(42) pg22160-22172

14 Oct 2016

27582494
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Wang, Y

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

The Journal of Experimental Medicine; 213(11) pg2413-2435

17 Oct 2016

27647349
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Kumagai, E

Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease.

Scientific Reports; 6 pg35282

14 Oct 2016

27739482
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Fujii, S

PGE

Scientific Reports; 6 pg36795

9 Nov 2016

27827428
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Bassani-Sternberg, M

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature Communications; 7 pg13404

21 Nov 2016

27869121
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Brien, M

Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction.

Journal of immunology (Baltimore, Md. : 1950); 198(1) pg443-451

1 Jan 2017

27903743
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Gibson, A L

Wnt7a Inhibits IL-1Î² Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis.

Scientific Reports; 7 pg41823

6 Feb 2017

28165497
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Majkowska, I

Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.

The Journal of Biological Chemistry; 292(16) pg6633-6643

21 Apr 2017

28270508
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Pattarini, L

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.

The Journal of Experimental Medicine; 214(5) pg1529-1546

1 May 2017

28428203
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Young, H L

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.

The Journal of Experimental Medicine; 214(6) pg1691-1710

5 Jun 2017

28450382
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Montoya, M M

A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950); 199(2) pg559-569

15 Jul 2017

28607111
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Wang, S

IL-1Î² increases asporin expression via the NF-ÎºB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration.

Scientific Reports; 7(1) pg4112

23 Jun 2017

28646230
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Zhang, Y

PD-L1 up-regulation restrains Th17 cell differentiation in

The Journal of Experimental Medicine; 214(9) pg2523-2533

4 Sep 2017

28710273
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Tripathi, P

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-Î²1.

Stem Cell Reports; 9(2) pg667-680

8 Aug 2017

28712846
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Weichand, B

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1Î².

The Journal of Experimental Medicine; 214(9) pg2695-2713

4 Sep 2017

28739604
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Li, F

TRPM2-mediated rise in mitochondrial Zn

Cell Death and Differentiation; 24(12) pg1999-2012

0 Dec 2017

28753206
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Mills, J D

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment.

Scientific Reports; 7(1) pg8089

14 Aug 2017

28808237
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Victor, A R

IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-ÎºB.

Journal of immunology (Baltimore, Md. : 1950); 199(7) pg2333-2342

1 Oct 2017

28842466
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Malik, S

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.

Nature Communications; 8(1) pg815

9 Oct 2017

28993609
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Mayer, U

miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.

Scientific Reports; 7(1) pg13297

16 Oct 2017

29038440
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Terenzi, R

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium.

Scientific Reports; 7(1) pg13293

16 Oct 2017

29038523
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Pierce, R W

A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.

The Journal of Experimental Medicine; 214(12) pg3497-3505

4 Dec 2017

29097442
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Secchi, M F

Heparanase and macrophage interplay in the onset of liver fibrosis.

Scientific Reports; 7(1) pg14956

2 Nov 2017

29097791
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Tehrani, F A

Induction of antimicrobial peptides secretion by IL-1Î² enhances humanÂ amniotic membrane for regenerative medicine.

Scientific Reports; 7(1) pg17022

5 Dec 2017

29208979
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Wu, X

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell; 172(3) pg423-438.e25

25 Jan 2018

29249360
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Chen, J

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.

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Regulation of IL-22BP in psoriasis.

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MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

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Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

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Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue.

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Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

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Choi, H

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Experimental & molecular medicine; 50(12) pg164

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Liu, L

Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator.

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Goff, J P

Influence of cytokines on the growth kinetics and immunophenotype of daughter cells resulting from the first division of single CD34(+)Thy-1(+)lin- cells.

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Bodaghi, B

Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells.

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Olee, T

IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses.

Journal of immunology (Baltimore, Md. : 1950); 162(2) pg1096-100

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Ma, C S

Early commitment of naÃ¯ve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Immunology and Cell Biology; 87(8) pg590-600

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Réthi, B

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells.

Blood; 107(7) pg2821-9

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Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.

Cell death & disease; 7(9) pge2367

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Øynebråten, I

Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.

Journal of immunology (Baltimore, Md. : 1950); 175(8) pg5358-69

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García-Arnandis, I

Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes.

PLoS ONE; 6(9) pge24591

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Nadeau-Vallée, M

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.

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Széles, L

1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.

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García-Arnandis, I

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.

Arthritis research & therapy; 12(4) pgR165

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Réthi, B

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells.

Blood; 107(7) pg2821-9

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Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.

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Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.

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Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes.

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Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.

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A network-centric approach to drugging TNF-induced NF-κB signaling.

ACS Medicinal Chemistry Letters; 10(1) pg860

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Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties.

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Wei, Z

Vitamin D Switches BAF Complexes to Protect β Cells.

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IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans.

Scientific Reports; 8(1) pg17005

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Schwartz, D M

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.

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Dosh, R H

Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease.

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A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta.

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NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.

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Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.

Cell Death & Disease; 10(2) pg45

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RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.

Oncogenesis; 8(6) pg37

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Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.

Nature Communications; 10(1) pg2387

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Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.

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Growth Factors & Cytokines