Recombinant Human IL-1β 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-01B Description: IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues. Source: E.coli Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) AA Sequence: APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 17.3 kDa Accession Number: P01584 Gene ID: 3553 Note: 1mg will be provided as 2x500μg. crossreactivity: Bacteria, Cow, Frog, Hamster, Horse, Human, Human + Hamster, Human + Mouse, Human + Rat, Monkey, Mouse, Pig, Rabbit, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Malik, S Title Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Citation Nature Communications; 8(1) pg815 PubMed Id 28993609 First Author Burzynski, L C Title Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION. Citation The Journal of Biological Chemistry; 290(41) pg25188-96 PubMed Id 26324711 First Author Fujii, S Title PGE Citation Scientific Reports; 6 pg36795 PubMed Id 27827428 product.subtitle.productreviews Existing reviews Very Good I purchased it as a proinflammatory stimulus for my experiment and it does work well. From: Yingjun | Date: 7/21/2020 × Very Good I purchased it as a proinflammatory stimulus for my experiment and it does work well. From: Yingjun | Date: 7/21/2020 Close
