Recombinant Human IL-6 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-06 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. Source: E.coli Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. The expected ED50 range is 0.001 - 0.020 ng/ml. Calculated Molecular Weight: 20.9 kDa Accession Number: P05231 Gene ID: 3569 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Cow, Human, Human + Hamster, Human + Mouse, Human + Virus, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Li, Y Title Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis. Citation Molecular Oncology; 16(15) pg2861-2880 PubMed Id 35665592 First Author Loef, E J Title Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses. Citation The Journal of Biological Chemistry; 298(7) pg102112 PubMed Id 35690148 First Author Raynard, C Title NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells. Citation Aging Cell; 21(7) pge13632 PubMed Id 35653631 product.subtitle.productreviews Existing reviews Quality product, Quick Arrival The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order. From: Todd | Date: 8/27/2020 × Quality product, Quick Arrival The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order. From: Todd | Date: 8/27/2020 Close
