Growth Factors & Cytokines

Recombinant Human IL-6

Product Details

Catalogue Number: 200-06
Description:

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Source: E.coli

Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. The expected ED50 range is 0.001 - 0.020 ng/ml.

Calculated Molecular Weight: 20.9 kDa

Accession Number: P05231

Gene ID: 3569

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kauts, M
Title
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Citation
Stem Cell Reports; 11(4) pg1009-1020
PubMed Id
First Author
Tusa, I
Title
Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.
Citation
Stem Cell Reports; 11(4) pg929-943
PubMed Id
First Author
Malik, S
Title
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Citation
Nature Communications; 8(1) pg815
PubMed Id

product.subtitle.productreviews

Existing reviews
Quality product, Quick Arrival
The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order.
From:  Todd | Date:  8/27/2020