Growth Factors & Cytokines

Recombinant Human IL-6

Product Details

Catalogue Number: 200-06
Description:
Recombinant Human IL-6

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Source: E.coli

Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. The expected ED50 range is 0.001 - 0.020 ng/ml.

Calculated Molecular Weight: 20.9 kDa

Accession Number: P05231

Gene ID: 3569

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Loef, E J
Title
Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses.
Citation
The Journal of Biological Chemistry; 298(7) pg102112
PubMed Id
First Author
Guo, Z
Title
Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer.
Citation
NPJ Precision Oncology; 6(1) pg34
PubMed Id
First Author
Thomas, G E
Title
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Citation
Nature Cell Biology; 24(6) pg872-884
PubMed Id

product.subtitle.productreviews

Existing reviews
Quality product, Quick Arrival
The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order.
From:  Todd | Date:  27/08/2020