Growth Factors & Cytokines

Recombinant Murine IL-1α

Product Details

Catalog Number: 211-11A
Description:

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells.  Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.  These cytokines have a broad range of activities including the stimulation of thymocyte proliferation  by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells.  However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.  Recombinant Murine IL-1α is a 17.9 kDa protein containing 156 amino acid residues.

Source: E.coli

Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.

Cross Reactivity:
Human, Mouse, Rat + Chicken
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.