Growth Factors & Cytokines

Recombinant Murine IL-6

Product Details

Catalogue Number: 216-16
Description:

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Source: E.coli

Synonyms: 26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 21.7 kDa

Accession Number: P08505

Gene ID: 16193

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Vanderkerken, K
Title
Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells.
Citation
Blood; 93(1) pg235-41
PubMed Id
First Author
Yuan, Q
Title
Generation of a novel stem cell factor-dependent mast cell progenitor.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(10) pg5143-6
PubMed Id
First Author
Hikida, M
Title
Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor.
Citation
The Journal of Experimental Medicine; 188(2) pg365-72
PubMed Id

product.subtitle.productreviews

Existing reviews
Very Good
Used to treat cell as a proinflammatory stimulus.
From:  Yingjun | Date:  7/21/2020