Recombinant Murine IL-6 1 评论Submit a Review 产品详情 产品编号: 216-16 产品描述: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues. Source: E.coli Synonyms: 26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 21.7 kDa Accession Number: P08505 Gene ID: 16193 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Hamster, Monkey, Mouse, Mouse + Bacteria, Mouse + Virus, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 血管生成/心血管 癌症 细胞培养 糖尿病/体重调节 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 过敏 移植 product.subtitle.recentcitations 第一作者 Dai, Y 标题 Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. 文献引用 Cell Reports; 40(12) pg111361 PubMed Id 36130501 第一作者 Zheng, X 标题 AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus. 文献引用 The EMBO Journal; 41(6) pge108016 PubMed Id 35191555 第一作者 Ahmed, N 标题 Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation. 文献引用 The Journal of Experimental Medicine; 219(1) PubMed Id 34817548 product.subtitle.productreviews 现有评论 Very Good Used to treat cell as a proinflammatory stimulus. 来自: Yingjun | 日期: 2020/7/21 × Very Good Used to treat cell as a proinflammatory stimulus. 来自: Yingjun | 日期: 2020/7/21 Close