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Recombinant Human IL-11

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Product Details

Catalogue Number: 200-11
Description:


Recombinant Human IL-11

IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts.  It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system.  IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells.  It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury.  Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.

Source: E.coli

Synonyms: Interleukin-11, AGIF (Adipogenesis inhibitory factor)

AA Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 19.3 kDa

Accession Number: P20809

Gene ID: 3589

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kauts, M
Title
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Citation
Stem Cell Reports; 11(4) pg1009-1020
PubMed Id
First Author
D'Souza, S S
Title
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Citation
Stem Cell Reports; 6(2) pg243-56
PubMed Id
First Author
Yu, L
Title
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.
Citation
The Journal of Experimental Medicine; 207(6) pg1183-95
PubMed Id