Recombinant Human IL-11 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-11 Description: IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues. Source: E.coli Synonyms: Interleukin-11, AGIF (Adipogenesis inhibitory factor) AA Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 19.3 kDa Accession Number: P20809 Gene ID: 3589 crossreactivity: Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Kauts, M Title Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. Citation Stem Cell Reports; 11(4) pg1009-1020 PubMed Id 30197119 First Author D'Souza, S S Title GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells. Citation Stem Cell Reports; 6(2) pg243-56 PubMed Id 26805448 First Author Yu, L Title SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. Citation The Journal of Experimental Medicine; 207(6) pg1183-95 PubMed Id 20457756
