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Recombinant Human IL-3

Product Details

Catalogue Number: 200-03
Description:

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages.  Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity.  Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles.  Many of the IL-3 activities depend upon co-stimulation with other cytokines.  IL-3 is a species-specific, variably glycosylated cytokine.  Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Source: E.coli

Synonyms: Interleukin-3, MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor

AA Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 15 kDa

Accession Number: P08700

Gene ID: 3562

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kauts, M
Title
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Citation
Stem Cell Reports; 11(4) pg1009-1020
PubMed Id
First Author
Tusa, I
Title
Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.
Citation
Stem Cell Reports; 11(4) pg929-943
PubMed Id
First Author
Lombardo, G
Title
Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.
Citation
Scientific Reports; 6 pg25689
PubMed Id

product.subtitle.productreviews

Existing reviews
IL3 for iPSC differentiation
Much cheaper than other options present in the market and extremely efficient. I'd highly recommend it as it is easy to reconstitute and very dependable.
From:  Meenakshi | Date:  09.07.2020