Chemokine

Recombinant Human MIP-1β (CCL4)

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Product Details

Catalogue Number: 300-09
Description:
Recombinant Human MIP-1β (CCL4)

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1β is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: Macrophage Inflammatory Protein-1β, CCL4, ACT-2

AA Sequence: APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.

Calculated Molecular Weight: 7.6 kDa

Accession Number: P13236

Gene ID: 6351

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Du, Y
Title
Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.
Citation
The Journal of Experimental Medicine; 219(7)
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First Author
Gurusamy, M
Title
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Citation
Nature Communications; 12(1) pg6798
PubMed Id
First Author
Murcia, J D
Title
Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk
Citation
Scientific Reports; 10(1) pg8019
PubMed Id