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Recombinant Human/Murine FGF-8b

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Product Details

Catalogue Number: 100-25
Description:

FGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-8, FGF-8b, AIGF, HBGF-8

AA Sequence: MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 5 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg.

Calculated Molecular Weight: 22.5 kDa

Accession Number: P55075

Gene ID: 2253

Note:

1mg will be provided as 2x500μg

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Zhang, X
Title
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Citation
The Journal of Biological Chemistry; 281(23) pg15694-700
PubMed Id
First Author
Lund, C
Title
Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells.
Citation
Stem Cell Reports; 7(2) pg149-57
PubMed Id
First Author
Loo, B
Title
Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b.
Citation
The Journal of Biological Chemistry; 277(36) pg32616-23
PubMed Id