Recombinant Murine IL-2

Product Details

Catalogue Number: 212-12

Description:

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues.

Source: E.coli

Synonyms: T-cell growth factor (TCGF), Aldesleukin

AA Sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 17.2 kDa

Accession Number: P04351

Gene ID: 16183

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Human + Mouse, Mouse,

Country Of Origin: USA

Not for human use.

Research Interest

Diabetes/Weight Regulation

Immune System

Inflammation

Neurobiology

Stem Cells & Differentiation

Wound Healing

Allergy

Transplantation

product.subtitle.recentcitations

First Author

Ashby, J F

Title

Microfluidic T Cell Selection by Cellular Avidity.

Citation

Advanced Healthcare Materials; 11(16) pge2200169

PubMed Id

35657072

First Author

Chang, J

Title

ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation.

Citation

Journal of immunology (Baltimore, Md. : 1950); 209(2) pg301-309

PubMed Id

35760518

First Author

Kalbasi, A

Title

Potentiating adoptive cell therapy using synthetic IL-9 receptors.

Citation

Nature; 607(7918) pg360-365

PubMed Id

35676488

product.subtitle.productreviews

Existing reviews

Product with great consistency

We have been using this cytokine for splenic T cells in numerous publications for the past 10 years. Great consistency!

From: Jin | Date: 21.07.2020

Reliable product

Our lab has been using Peprotech cytokines for many years because of its quality and reliability. Would highly recommend for assays in which murine T cells, splenocytes, or T cell clones need to be grown and stimulated.

From: Diane | Date: 26.08.2020

For in vitro NKs expansion

We used this product for in vitro NKs expansion

From: Aitziber | Date: 26.08.2020

Great consistent mouse recombinant IL-2

We have been using this recombinant mouse IL-2 for almost 20 years now in the lab. Our T cell cultures grow and expand very well with IL-2.

From: Chirag | Date: 31.08.2020

Wachstumsfaktoren & Zytokine