Chemokine

Recombinant Rat GRO/KC (CXCL1)

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Product Details

Catalogue Number: 400-10
Description:


Recombinant Rat GRO/KC (CXCL1)

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant Rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids, including the 'ELR' motif common to the CXC chemokine family that binds to CXCR1 or CXCR2.

Source: E.coli

Synonyms: MGSAα, CXCL1, NAP-3, GRO1, GRO/MGSA (human), KC (murine), CINC (rat)

AA Sequence: APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P14095

Gene ID: 81503

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Nabah, Y N
Title
Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines.
Citation
Circulation; 110(23) pg3581-6
PubMed Id
First Author
Boespflug, N D
Title
ATF3 is a novel regulator of mouse neutrophil migration.
Citation
Blood; 123(13) pg2084-93
PubMed Id
First Author
Nasser, M W
Title
CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.
Citation
The Journal of Biological Chemistry; 282(9) pg6906-15
PubMed Id