Recombinant Human BCA-1 (CXCL13) 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-47 Description: BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor, CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes, and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant Human BCA-1 is a 10.3 kDa protein containing 87 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines. Source: E.coli Synonyms: B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand AA Sequence: VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml. Calculated Molecular Weight: 10.3 kDa Accession Number: O43927 Gene ID: 10563 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Human + Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Wound Healing product.subtitle.recentcitations First Author Seda, V Title FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia. Citation Blood; 138(9) pg758-772 PubMed Id 33786575 First Author Gimenez, N Title Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia Citation Scientific Reports; 10(1) pg22153 PubMed Id 33335123 First Author Yasuoka, H Title Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis Citation Scientific Reports; 10(1) pg10377 PubMed Id 32587357 product.subtitle.productreviews Existing reviews For migration assay We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended. From: Jhomary | Date: 8/26/2020 × For migration assay We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended. From: Jhomary | Date: 8/26/2020 Close
