Recombinant Human BCA-1 (CXCL13) 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-47 Description: BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor, CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes, and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant Human BCA-1 is a 10.3 kDa protein containing 87 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines. Source: E.coli Synonyms: B cell Attracting Chemokine-1, CXCL13, BLC (mouse), BLR1 Ligand AA Sequence: VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml. Calculated Molecular Weight: 10.3 kDa Accession Number: O43927 Gene ID: 10563 crossreactivity: Bacteria, Human, Human + Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Wound Healing product.subtitle.recentcitations First Author Le Roux, D Title Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells. Citation Blood; 119(1) pg95-105 PubMed Id 22049514 First Author Chao, M P Title Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Citation Blood; 118(18) pg4890-901 PubMed Id 21828138 First Author Trinidad, E M Title An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression. Citation Blood; 114(24) pg5081-90 PubMed Id 19828693 product.subtitle.productreviews Existing reviews For migration assay We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended. From: Jhomary | Date: 8/26/2020 × For migration assay We have been using this chemokine to test the ability of our cells to migrate and we always get really good results when working with PBMCs. Highly recommended. From: Jhomary | Date: 8/26/2020 Close
