Growth Factors & Cytokines

Recombinant Human GDF-15/MIC-1 (CHO derived)

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Product Details

Catalogue Number: 120-28C
Description:

GDF-15 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains.  The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.

Source: CHO cells

Synonyms: Growth/Differentiation Factor-15, MIC-1, Macrophage Inhibitory Cytokine 1, Placental TGFβ, Prostate Differentiation Factor (PDF), PLAB, NRG-1

AA Sequence (monomer): ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osteoblastcells. The expected ED50 for this effect is 75-200 ng/ml.

Calculated Molecular Weight: 24.6 kDa

Accession Number: Q99988

Gene ID: 9518

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Remšík, J
Title
TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
Citation
Scientific Reports; 10(1) pg11396
PubMed Id
First Author
Guccini, I
Title
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.
Citation
Cancer Cell; 39(1) pg68-82.e9
PubMed Id