Growth Factors & Cytokines

Recombinant Human Oncostatin M (209 a.a.)

Product Details

Catalogue Number: 300-10T
Description:
Recombinant Human Oncostatin M (209 a.a.)

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis.  Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation.  It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines.  It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.  OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.  Human OSM is active on murine cells.  The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein.  Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide, and generates the mature OSM form.  Recombinant Human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues.

Source: E.coli

Synonyms: OSM

AA Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 23.6 kDa

Accession Number: P13725

Gene ID: 5008

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Mass, O A
Title
Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery
Citation
Scientific Reports; 11(1) pg16174
PubMed Id
First Author
Hara, T
Title
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Citation
Cancer Cell; 39(6) pg779-792.e11
PubMed Id
First Author
Passaretta, F
Title
Differential response to hepatic differentiation stimuli of amniotic epithelial cells isolated from four regions of the amniotic membrane.
Citation
Journal of Cellular and Molecular Medicine; 24(7) pg4350-4355
PubMed Id

product.subtitle.productreviews

Existing reviews
Excellent differentiation growth factor!
Like many of their other growth factors and cytokines, Peprotech oncostatin M helps my differentiation of human iPSCs run smoothly. I can count on their growth factors to arrive quickly and well-packaged. Once stored under clearly explained storage conditions, I don't worry about their stability. When differentiating human iPSCs, I get reproducible efficiencies of differentiation each time I use P... reviews.showmore
From:  Kendall | Date:  8/26/2020