Growth Factors & Cytokines

Recombinant Murine IL-10

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Product Details

Catalogue Number: 210-10
Description:
Recombinant Murine IL-10

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes.  IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α.  Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions.  Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells.  Recombinant Murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.

Source: E.coli

Synonyms: B-TCGF, CSIF, TGIF

AA Sequence: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: PeproTech's Murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 18.7 kDa

Accession Number: P18893

Gene ID: 16153

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Spalinger, M R
Title
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Citation
Mucosal Immunology; 15(1) pg74-83
PubMed Id
First Author
Alexander, A F
Title
Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response.
Citation
Cell Reports; 36(12) pg109728
PubMed Id
First Author
Song, H
Title
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
Citation
Nature Communications; 12(1) pg5522
PubMed Id