Chemokines

Recombinant Murine MCP-3 (CCL7)

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Product Details

Catalogue Number: 250-08
Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine MCP-3 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-3, CCL7, MARC

AA Sequence: QPDGPNASTC CYVKKQKIPK RNLKSYRRIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTP TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract BaF3 cells expressing human CCR2 receptor using a concentration range of 300-500 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: Q03366

Gene ID: 20306

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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First Author
Yagawa, Y
Title
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
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Scientific Reports; 7(1) pg15996
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Wang, W
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Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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Nature Communications; 12(1) pg4441
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Sokol, C L
Title
The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response.
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Immunity; 49(3) pg449-463.e6
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