Chemokines

Recombinant Murine MIG (CXCL9)

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Product Details

Catalogue Number: 250-18
Description:

MIG, a CXC chemokine, is produced by IFN-γ stimulated monocytes, macrophages and endothelial cells.  It signals through the CXCR3 receptor.  MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities, including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors.  Human MIG is active on murine cells.  Recombinant Murine MIG is a 12.2 kDa protein containing 105 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: Monokine Induced by Interferon-gamma, CXCL9

AA Sequence: TLVIRNARCS CISTSRGTIH YKSLKDLKQF APSPNCNKTE IIATLKNGDQ TCLDPDSANV KKLMKEWEKK INQKKKQKRG KKHQKNMKNR KPKTPQSRRR SRKTT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human activated T cells cultured in the presence of IL-2 using a concentration range of 50.0-150.0 ng/ml.

Calculated Molecular Weight: 12.2 kDa

Accession Number: P18340

Gene ID: 17329

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Shin, H
Title
CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.
Citation
Nature Communications; 7 pg13346
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First Author
Thompson, B D
Title
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
Citation
The Journal of Biological Chemistry; 282(13) pg9547-55
PubMed Id
First Author
Sakthivel, S K
Title
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.
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Journal of Immune Based Therapies and Vaccines; 6 pg6
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