Chemokines

Recombinant Human IP-10 (CXCL10)

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Product Details

Catalogue Number: 300-12
Description:


Recombinant Human IP-10 (CXCL10)

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Human IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: γ-Interferon Inducible Protein 10, CXCL10, crg-2

AA Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml.

Calculated Molecular Weight: 8.6 kDa

Accession Number: P02778

Gene ID: 3627

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Tiffany, H L
Title
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
Citation
The Journal of Experimental Medicine; 186(1) pg165-70
PubMed Id
First Author
Fagète, S
Title
Dual specificity of anti-CXCL10-CXCL9 antibodies is governed by structural mimicry.
Citation
The Journal of Biological Chemistry; 287(2) pg1458-67
PubMed Id
First Author
Kirouac, D C
Title
Dynamic interaction networks in a hierarchically organized tissue.
Citation
Molecular Systems Biology; 6 pg417
PubMed Id