IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Human IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.
γ-Interferon Inducible Protein 10, CXCL10, crg-2
VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml.
Calculated Molecular Weight: