Chemokine

Recombinant Human IP-10 (CXCL10)

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Product Details

Catalogue Number: 300-12
Description:
Recombinant Human IP-10 (CXCL10)

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Human IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: γ-Interferon Inducible Protein 10, CXCL10, crg-2

AA Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml.

Calculated Molecular Weight: 8.6 kDa

Accession Number: P02778

Gene ID: 3627

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Du, Y
Title
Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.
Citation
The Journal of Experimental Medicine; 219(7)
PubMed Id
First Author
Gurusamy, M
Title
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Citation
Nature Communications; 12(1) pg6798
PubMed Id
First Author
Ofir-Birin, Y
Title
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
Citation
Nature Communications; 12(1) pg4851
PubMed Id