Chémokines

Recombinant Human IP-10 (CXCL10)

Product Details

Catalogue Number: 300-12
Description:

IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Human IP-10 is an 8.6 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: γ-Interferon Inducible Protein 10, CXCL10, crg-2

AA Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50 ng/ml.

Calculated Molecular Weight: 8.6 kDa

Accession Number: P02778

Gene ID: 3627

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Shen, H
Title
Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.
Citation
Journal of Virology; 73(1) pg728-37
PubMed Id
First Author
Agostini, C
Title
Involvement of the IP-10 chemokine in sarcoid granulomatous reactions.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(11) pg6413-20
PubMed Id
First Author
Petersen, F
Title
A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4347-55
PubMed Id