Facteurs de Croissance et Cytokines

Recombinant Human FGF-19

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Product Details

Catalogue Number: 100-32
Description:

The FGF family plays central roles during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-19, a member of the FGF family, is a high-affinity heparin-dependent ligand for FGFR4. FGF-19 is expressed during brain development and embryogenesis. Recombinant Human FGF-19 is a 21.8 kDa protein containing 195 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-19, FGFJ

AA Sequence: MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 100-150 ng/ml.

Calculated Molecular Weight: 21.8 kDa

Accession Number: O95750

Gene ID: 9965

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kanzaki, H
Title
The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma.
Citation
Scientific Reports; 11(1) pg5303
PubMed Id
First Author
Xu, Y
Title
Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma.
Citation
Biochemical and Biophysical Research Communications; 446(1) pg54-60
PubMed Id
First Author
Tomiyama, K
Title
Relevant use of Klotho in FGF19 subfamily signaling system in vivo.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 107(4) pg1666-71
PubMed Id