Chémokines

Recombinant Human MCP-2 (CCL8)

Product Details

Catalogue Number: 300-15
Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-2 is an 8.9 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-2, CCL8, HC14

AA Sequence: QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.9 kDa

Accession Number: P80075

Gene ID: 6355

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wang, J M
Title
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4309-17
PubMed Id
First Author
Bodaghi, B
Title
Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: withdrawal of chemokines from the environment of cytomegalovirus-infected cells.
Citation
The Journal of Experimental Medicine; 188(5) pg855-66
PubMed Id
First Author
Luft, T
Title
Type I IFNs enhance the terminal differentiation of dendritic cells.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(4) pg1947-53
PubMed Id