Chémokines

Recombinant Human PF-4 (CXCL4)

Product Details

Catalogue Number: 300-16
Description:

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Source: E.coli

Synonyms: Platelet Factor-4, CXCL4, Oncostatin A, Ironplact

AA Sequence: EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P02776

Gene ID: 5196

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Matsumoto, K
Title
Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis.
Citation
Scientific Reports; 11(1) pg222
PubMed Id
First Author
Lee, A W
Title
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Citation
The Journal of Biological Chemistry; 294(29) pg11199-11212
PubMed Id
First Author
Carvalheiro, T
Title
Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis.
Citation
Arthritis & rheumatology (Hoboken, N.J.); 71(10) pg1711-1722
PubMed Id