Recombinant Human PF-4 (CXCL4) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-16 Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. Source: E.coli Synonyms: Platelet Factor-4, CXCL4, Oncostatin A, Ironplact AA Sequence: EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml. Calculated Molecular Weight: 7.8 kDa Accession Number: P02776 Gene ID: 5196 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Mouse, Parasite References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Wound Healing product.subtitle.recentcitations First Author Matsumoto, K Title Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis. Citation Scientific Reports; 11(1) pg222 PubMed Id 33420306 First Author Carvalheiro, T Title Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis. Citation Arthritis & rheumatology (Hoboken, N.J.); 71(10) pg1711-1722 PubMed Id 31012544 First Author Lee, A W Title A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Citation The Journal of Biological Chemistry; 294(29) pg11199-11212 PubMed Id 31167786
