Recombinant Human PF-4 (CXCL4)

Product Details

Catalogue Number: 300-16

Description:

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Source: E.coli

Synonyms: Platelet Factor-4, CXCL4, Oncostatin A, Ironplact

AA Sequence: EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P02776

Gene ID: 5196

crossreactivity:

Bacteria, Human, Mouse, Parasite, Trout

Country Of Origin: USA

Not for human use.

Research Interest

Angiogenesis/Cardiovascular

product.subtitle.recentcitations

First Author

Matsumoto, K

Title

Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis.

Citation

Scientific Reports; 11(1) pg222

PubMed Id

33420306

First Author

Schweickart, V L

Title

CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines.

Citation

The Journal of Biological Chemistry; 275(13) pg9550-6

PubMed Id

10734104

First Author

Singh, K

Title

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Citation

Scientific Reports; 7(1) pg4267

PubMed Id

28655871

Chemokines