Recombinant Murine IL-9 0 ReviewsSubmit a Review Product Details Catalogue Number: 219-19 Description: IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erythroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant Murine IL-9 is a 14.3 kDa protein of 127 amino acid residues, including 10 cysteine residues that are fully conserved between the human and murine proteins. Source: E.coli Synonyms: p40 cytokine, T-cell growth factor p40 AA Sequence: MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of human MO7e cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. Calculated Molecular Weight: 14.3 kDa Accession Number: P15247 Gene ID: 16198 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System product.subtitle.recentcitations First Author Piseddu, I Title Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. Citation Journal of immunology (Baltimore, Md. : 1950); 205(8) pg2056-2065 PubMed Id 32907996 First Author Venturutti, L Title TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Citation Cell; 182(2) pg297-316.e27 PubMed Id 32619424 First Author Delacher, M Title Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. Citation Immunity; 52(2) pg295-312.e11 PubMed Id 31924477
