Facteurs de Croissance et Cytokines

Recombinant Murine TPO

Product Details

Catalogue Number: 315-14
Description:

TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. Recombinant Murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

Source: E.coli

Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

AA Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Calculated Molecular Weight: 18.7 kDa

Accession Number: P40226

Gene ID: 21832

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Ahmed, N
Title
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
Citation
The Journal of Experimental Medicine; 219(1)
PubMed Id
First Author
Yan, R
Title
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression
Citation
Cell Death & Disease; 12(11) pg955
PubMed Id
First Author
Gerosa, R C
Title
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.
Citation
Blood Advances; 5(23) pg5002-5015
PubMed Id

product.subtitle.productreviews

Existing reviews
Recombinant Murine SCF
We use this product in our mouse media, it works well!
From:  Nichole | Date:  26/08/2020