Facteurs de Croissance et Cytokines

Recombinant Murine TPO

Product Details

Catalogue Number: 315-14
Description:

TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. Recombinant Murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

Source: E.coli

Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

AA Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Calculated Molecular Weight: 18.7 kDa

Accession Number: P40226

Gene ID: 21832

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Guo, S
Title
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 109(41) pg16636-41
PubMed Id
First Author
He, H
Title
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Citation
Blood; 136(2) pg183-198
PubMed Id
First Author
Zhao, L
Title
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Citation
Blood; 119(6) pg1511-21
PubMed Id

product.subtitle.productreviews

Existing reviews
Recombinant Murine SCF
We use this product in our mouse media, it works well!
From:  Nichole | Date:  26/08/2020