Neurotrophins

Recombinant Rat CNTF

Product Details

Catalogue Number: 450-50
Description:

CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Rat CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion.

Source: E.coli

Synonyms: Ciliary Neurotrophic Factor

AA Sequence: AFAEQTPLTL HRRDLCSRSI WLARKIRSDL TALMESYVKH QGLNKNINLD SVDGVPVAST DRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPT EGDFHQAIHT LMLQVSAFAY QLEELMVLLE QKIPENEADG MPATVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRVISS HQMGISALES HYGAKDKQM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using a concentration range of 25.0-35.0 ng/ml.

Calculated Molecular Weight: 22.7 kDa

Accession Number: P20294

Gene ID: 25707

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Anderson, C N
Title
A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 19(2) pg664-73
PubMed Id
First Author
Vicario-Abejón, C
Title
Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7256-71
PubMed Id
First Author
Hensel, N
Title
Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in spinal muscular atrophy.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 118(18)
PubMed Id