Chemokine

Recombinant Murine C10 (CCL6)

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Product Details

Catalogue Number: 250-06
Description:

Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant Murine C10 is a 10.7 kDa protein containing 95 amino acid residues.

Source: E.coli

Synonyms: CCL6, MRP-1

AA Sequence: GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract Balb/c mouse spleen MNCs using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 10.7 kDa

Accession Number: P27784

Gene ID: 20305

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Núñez, V
Title
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 107(23) pg10626-31
PubMed Id
First Author
Singh, K
Title
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Citation
Scientific Reports; 7(1) pg4267
PubMed Id
First Author
Krishnan, V
Title
Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1
Citation
Communications Biology; 3(1) pg524
PubMed Id